Vitamin r review12/25/2022 ![]() ![]() Congestive heart failure is the major cardiovascular illness impacted by vitamin D insufficiency, accounting for most hospitalizations, healthcare spending, morbidity, and death, predominantly affecting middle-aged and elderly adults. Cardiovascular disease is the most prevalent chronic illness worldwide and is responsible for 30% of fatalities, placing a significant strain on healthcare systems. Morbidity and mortality of CHF increase progressively with age. ![]() The prevalence of CHF is approximately 1% to 3% in western societies. Muscle weakness and early fatigue are the two primary symptoms of CHF patients. Vitamin D treatment inhibits ventricular remodeling and improves cardiac function in a patient with CHF.Ĭongestive heart failure (CHF) is a cardiac dysfunction syndrome characterized by a reduced left ventricular ejection fraction (LVEF) associated with water and sodium retention. Vitamin D supplementation lowers serum inflammatory marker levels and improves the quality of life in CHF patients. ![]() There were 10 randomized controlled trials and three observational studies. Using the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020 guidelines, removing duplicates, screening of title and abstract, application of eligibility criteria, and quality appraisal, 13 articles were retained for systemic review. This systematic review used research from the previous ten years (January 2012-2022) retrieved from the following databases: PubMed/PMC (PubMed Central)/Medline and Cochrane Library. It aims to evaluate the association between vitamin D and congestive heart failure (CHF). Vitamin D supplementation might improve ventricular remodeling in heart failure patients, however, this is still unclear. There are some hints in recent experimental research on how vitamin D can have cardioprotective effects. Additionally, patients with low vitamin D levels are more likely to have diabetes, hypertension, atherosclerosis, and other precursor conditions to heart failure. Patients with heart failure who have low vitamin D levels experience worse outcomes, which associate with known clinical correlations and biomarkers. Heart failure (HF) is still the leading cause of mortality worldwide. There is a need for large, well-resourced clinical trials to close the gaps in our current understanding of the nature of the associations of vitamin B12 insufficiency and neurodegenerative disease.Many studies have shown that vitamin D is a crucial modulator of hypertension and cardiovascular illness, including heart failure. Vitamin B12 therapy does not improve cognition in patients without pre-existing deficiency. There is a small subset of dementias that are reversible with vitamin B12 therapy and this treatment is inexpensive and safe. Results: Vitamin B12 levels in the subclinical low-normal range (19.9 μmol/L).Ĭonclusion: Low serum vitamin B12 levels are associated with neurodegenerative disease and cognitive impairment. Seventeen studies reported on the efficacy of vitamin B12 therapy for these conditions. Methods: A systematic literature search identified 43 studies investigating the association of vitamin B12 and cognitive impairment or dementia. In addition, we reviewed the evidence as to whether vitamin B12 therapy is efficacious for cognitive impairment and dementia. The potential impact of comorbidities and medications associated with vitamin B12 derangements were also investigated. Background: This review examines the associations between low vitamin B12 levels, neurodegenerative disease, and cognitive impairment.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |